Endocannabinoids and Mental Health
Endocannabinoids and Mental Health
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Endocannabinoids and Mental Health
#CBD #Mentalhealth #cannabis
Dr. Dawn-Elise Snipes
Objectives
~ Explore the role of the endocannabinoid system in
~ Mood disorders
~ Cognitive disorders
~ Autoimmune and inflammatory disorders
~ Pain
~ Stress
Intro
~ The eCB system targets both monoamines and the HPA axis, which is also dysregulated during stress-induced psychiatric disorders
~ Hyperactivity of endocannabinoid signaling contributes to excessive intake and storage of high-calorie foods, while endocannabinoid hypoactivity is a risk factor for the development of depression, anxiety and post-traumatic stress disorder
~ The ECS is comprised of endogenous cannabinoids (endocannabinoids), cannabinoid receptors, and the enzymes responsible for the synthesis and degradation of endocannabinoids
~ Endogenous cannabinoids are endogenous lipids that engage cannabinoid receptors
~ The first discovered and best-characterized endocannabinoids are anandamide (arachidonoyl ethanolamide) and 2-arachidonoyl glycerol (2-AG)
~ Both 2 AG and anandamide are agonists for CB1 and CB2 receptors
~ In systems with low receptor expression, anandamide can antagonize the effects of more efficacious agonists
~ On demand, endocannabinoids are liberated in and released into the extracellular space. This contrasts with classical neurotransmitters that are synthesized ahead of time and stored in synaptic vesicles
~ CB1 receptors are abundant in the central nervous system (CNS), particularly in cortex, basal ganglia, hippocampus, and cerebellum
~ CB2 receptors are expressed at much lower levels in the CNS
~ Physical exercise mobilizes endocannabinoids, which could contribute to refilling of energy stores and also to the analgesic and mood-elevating effects of exercise.
~ A second important role for endocannabinoid signaling is to restore homeostasis following stress
ECS and Neurotransmitters
~ Changes in the ECS are involved in several psychiatric disorders.
~ Serotonin
~ eCBs reduce serotonin release in the CNS via the activation of CB1 receptors
~ Early evidence for a role of eCB signaling in the regulation of the 5-HT system suggests a high level of functional overlap between the 5-HT and eCB systems. Both 5-HT and eCB systems regulate body temperature, feeding, sleep and arousal and emotional processes
~ Dopamine
~ CB1 receptors tightly regulate DA neuronal activity
~ CB1 receptors are expressed at presynaptic inputs to DA neurons and facilitate or suppress DAergic neuron activity depending on their location
Alzheimer’s and Neurodegenerative Disorders
~ Cannabinoid receptor agonists such as AEA have been shown to provide protection against neurotoxicity
~ Activation of CB1 and CB2 attenuates Aβ (beta amyloid)-induced neuroinflammation, neurodegeneration and spatial memory impairment
Pain and Inflammation
~ Activation of the CB2 and adenosine receptors leads to a decrease oxidative stress and inflammation
~ CBD is one of the main pharmacologically active phytocannabinoids
~ It is non-psychoactive, but has many beneficial pharmacological effects, including anti-inflammatory, antioxidant, anxiolytic, antidepressant, antipsychotic, and anticonvulsant properties
Anxiety
~ Chronic stress and steroid treatments are both known to impair endocannabinoid signaling at multiple levels,
~ Stress-related down-regulation of the CB1 receptor leads to greater changes in glutamatergic signaling and excitotoxicity within the PFC following chronic stress
~ It has been repeatedly shown that CBD and THC concurrently decrease anxiety and depression
~ Essential oils, terpenes can activate CB1 and CB2 receptors and are associated with cognitive and mood effects.
Interventions
~ Omega-3 and 6 fatty acids
~ Flavonoids which inhibit endocannabinoid degradation
~ Meditation
~ Exercise
~ Sex
Summary
~ The endocannabinoid system interacts with most other bodily functions and neurotransmitters.
~ Problems in the ECS are associated with
~ Chronic pain and inflammation
~ GI disorders
~ Mood disorders
~ Neurodegenerative disorders
~ Metabolic disorders
~ Endocannabinoids are created partially from lipids, particularly Omega 3 and 6s
~ Reducing HPA-Axis activation and increasing serotonin and dopamine will all increase EC levels
TIMESTAMPS
00:00 Beginning
01:49 Introduction to the endocannabinoid system
17:35 Endocannabinoid system and neurotransmitters serotonin and dopamine
31:10 Gut Health and the Endocannabinoid Receptors
38:27 ECS and Pain and inflammation
BIOCHEMISTRY DOESN’T UNDERSTAND ITS SYNERGISTICALLY PHYSICAL PROPERTIES BECAUSE THEY ARE NOT A PHYSICIST
Great presentation
Thank you very much
great video, thank you!
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Day 1 without marijuana. I’ve smoked about 2g per day going on 10 years. My stomach is a total mess this morning. I could only sleep for about 4 hours. I have a strong craving and my brain won’t stop suggesting a quick call to my dealer. Chances are very slim that I’ll make it. I ask myself why I would put myself through this for such a small chance of success… but being dependent on marijuana is so much worse than any of that. I’ll take this small chance and if I miss I’ll just roll the dice again until I hit. I won’t allow another decade to be altered by my addiction. I’m ready to find a wife and I’m building my retirement. Those are not things to do while you’re stoned. I don’t want to spend the rest of my life wondering who I might have wound up with if I was sober… or what better career decisions I might have made. I don’t need to feel good all the time, I need to be effective. I have important work to do.
I really love the idea of a wellness retreat. Bliss in nature + CEU credits to boot. Genius!
Is it REALLY a "personality disorder" when it’s deliberately induced by the dual torture of organized gang stalking and the discrediting that goes along with this form of covert long term torture? I was used as living, involuntary human test subject, AND I’M SEVERELY DAMAGED AND IT’S COMPREHENSIVE. THERE IS NOTHING MORE EVIL THAN TO MALICIOUSLY DELIBERATELY BLIGHT A HUMAN BEING THRU THIS, AND THEN SOULLESSLY LIE ABOUT IT, AS IF TARGETS OF THIS VICIOUS LONG TERM ATTACK ARE COMPLETELY DISPOSABLE.
Everyone needs to know I was returned from ‘death’ to show the WORLD what our ENDOCANNABINOID SYSTEM does. THC saved my brain from OXYGEN DEPRIVATION, BRAIN SWELLING & is restoring my 5.5 TBI. (Traumatic Brain Injury) ❤
Thank you LORD.
Around 37:50 your commercial is starting when you are speaking. I love this so far, thanks so much. I really really like this it gives me hope. I have horrible food allergies and gut issues constantly. I also poo blood almost every time. They say it is hemmeroids but seriously it has been a long time. I have ADHypoD and the more I learn about bpd I might have been suffering with it as well. My daughter/son has BPD traits and is 16, so I have been obsessing about trying to learn about it, and how to deal with it. She is a quiet bpd. I used to smoke a lot of weed in the late 90s and 2000s. So much guilt and hearing about these kinds of things help me feel as though I was self medicating, and that shouldn’t have been frowned upon. Though it has messed with my asthma. I might look into getting a script for something though I might need to travel an 1.50 hours away because in a place like this, everything is still pretty backward, even though it has been legal in Ohio for quite some time. Thanks
cbn or cannabinol with thc, cbd, and cbg cannabigerol is my favorite for ptsd.
Lol. This is a great topic of discussion on a date.
I viewed the video twice. Thank you for explaing in simple terms. Greetings from Ecuador, Portoviejo city. Totally amased by all of it
Hi. I am a 42 year old Irish guy, and have suffered from birth with my body trying and not being able to destroy the virus in Chronic sinusitis, thus leading to FMS/Depression. This video is the best I have seen in 25 years. I recently recovered from the COVID virus, my FMS symptoms and firing glutamic acid CNS multiplied by about 5.Therefore my conclusion is that the autoimmune hypothesis on FMs is true. Thankyou for this video and sharing of this information.
Thank you soooooo much . Great topic and beautiful explanation
I’m high and I love videos like this! I love CBD too!
Do you have any published papers on this subject I can reference for school? Thank you for making a video! It’s much easier to digest in video format
Synergistically. That is how. PHYSIOLOGY NEEDS TO FACE REALITY ITS SYNERGISTIC
Are you the same lady that hosts the Beach Broadcast channel here on YTube?